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mesothelin, CRISPR-Cas9, PD-1, TCR

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Solid Tumor, Adult Trial in Beijing (anti-mesothelin CAR-T cells)

Unknown status
  • Solid Tumor, Adult
  • anti-mesothelin CAR-T cells
  • Beijing, China
    Biotherapeutic Department and Hematology Department of Chinese P
Aug 6, 2020

COVID-19 Respiratory Infection Trial (PD-1 and ACE2 Knockout T Cells)

Not yet recruiting
  • COVID-19 Respiratory Infection
  • PD-1 and ACE2 Knockout T Cells
  • (no location specified)
Aug 13, 2021

Beta-Thalassemia, Thalassemia, Genetic Diseases, Inborn Trial in Worldwide (CTX001)

Active, not recruiting
  • Beta-Thalassemia
  • +4 more
  • CTX001
  • Stanford, California
  • +11 more
Nov 30, 2022

Transfusion Dependent Beta-Thalassaemia Trial in Guangzhou, Shenzhen, Tianjin (ET-01)

Active, not recruiting
  • Transfusion Dependent Beta-Thalassaemia
  • ET-01
  • Guangzhou, Guangdong, China
  • +3 more
May 9, 2022

Clear Cell Renal Cell Carcinoma, Cervical Carcinoma, Esophageal Carcinoma Trial in Nashville (CTX131)

Recruiting
  • Clear Cell Renal Cell Carcinoma
  • +4 more
  • CTX131
  • Nashville, Tennessee
    Research Site 1
Mar 21, 2023

NSCLC, Metastatic Non Small Cell Lung Cancer, Stage IV NSCLC Trial in Duarte, Minneapolis (Fludarabine, Cyclophosphamide, CISH

Not yet recruiting
  • Carcinoma, Non-Small-Cell Lung
  • +5 more
  • Duarte, California
  • +1 more
Dec 7, 2022

B-cell Lymphoma, Non-Hodgkin Lymphoma, B-cell Malignancy Trial (CTX112)

Not yet recruiting
  • B-cell Lymphoma
  • +7 more
  • CTX112
  • (no location specified)
Dec 12, 2022

Multiple Myeloma, Melanoma, Synovial Sarcoma Trial in Philadelphia (biological, drug, device)

Terminated
  • Multiple Myeloma
  • +3 more
  • NY-ESO-1 redirected autologous T cells with CRISPR edited endogenous TCR and PD-1
  • +3 more
  • Philadelphia, Pennsylvania
    University of Pennsylvania
Oct 9, 2020

T Cell Lymphoma Trial in Australia, Canada, United States (CTX130)

Recruiting
  • T Cell Lymphoma
  • CTX130
  • Duarte, California
  • +9 more
May 16, 2022

Multiple Myeloma Trial in Worldwide (CTX120)

Active, not recruiting
  • Multiple Myeloma
  • CTX120
  • Chicago, Illinois
  • +9 more
Jul 14, 2022

Non-hodgkin Lymphoma,B Cell Trial in Beijing (Autologous CD19-STAR-T cell, Fludarabine, Cyclophosphamide)

Recruiting
  • Non-hodgkin Lymphoma,B Cell
  • Autologous CD19-STAR-T cell
  • +2 more
  • Beijing, Beijing, China
  • +1 more
Nov 21, 2022

Beta-Thalassemia Trial in China (BRL-101)

Recruiting
  • Beta-Thalassemia
  • Guangzhou, Guangdong, China
  • +3 more
Nov 7, 2022

Viral Keratitis, Blindness Eye, Herpes Simplex Virus Infection Trial in Shanghai (BD111 Adult single group Dose)

Completed
  • Viral Keratitis
  • +3 more
  • BD111 Adult single group Dose
  • Shanghai, Shanghai, China
    Eye & Ent Hospital of Fudan University
Aug 20, 2022

Sickle Cell Disease Trial in Los Angeles, Oakland (CRISPR_SCD001)

Not yet recruiting
  • Sickle Cell Disease
  • Los Angeles, California
  • +1 more
Apr 25, 2022

Metastatic Pancreatic Adenocarcinoma, Recurrent Pancreatic Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Trial in Canada,

Active, not recruiting
  • Metastatic Pancreatic Adenocarcinoma
  • +5 more
  • Anetumab Ravtansine
  • +5 more
  • Birmingham, Alabama
  • +44 more
Feb 2, 2023

Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma Trial (PACE CART19)

Withdrawn
  • Acute Lymphoblastic Leukemia
  • +2 more
  • PACE CART19
  • (no location specified)
Mar 9, 2022

B-cell Malignancy, Non-Hodgkin Lymphoma, B-cell Lymphoma Trial in Worldwide (CTX110)

Recruiting
  • B-cell Malignancy
  • +3 more
  • CTX110
  • Los Angeles, California
  • +27 more
May 6, 2022

Pancreatic Cancer Trial in Guangzhou (TCR-T therapy)

Recruiting
  • Pancreatic Cancer
  • TCR-T therapy
  • Guangzhou, Guangdong, China
    Sun Yat-sen Memorial Hospital
Aug 10, 2022

Stem Cells in NF1 Tumors of the Central Nervous System

Suspended
  • Neurofibromatosis Type 1
  • Tumors of the Central Nervous System
  • Collection of Stem Cells
  • Washington, District of Columbia
    Children's National Medical Center
Mar 8, 2022

Gene Editing as a Therapeutic Approach for Rett Syndrome

Recruiting
  • Rett Syndrome
  • Gene editing in vitro
  • Siena, Italy
    University of Siena
Feb 13, 2023

Thalassemia, Beta, Thalassemia Major Trial in Tianjin (VGB-Ex01)

Not yet recruiting
  • Thalassemia, Beta
  • Thalassemia Major
  • VGB-Ex01
  • Tianjin, Tianjin, China
    Regenerative Medicine Center
Sep 11, 2023

Mesothelioma, Mesotheliomas Pleural, Mesothelioma, Malignant Trial in Bethesda, Nashville (TC-510, Fludarabine,

Recruiting
  • Mesothelioma
  • +14 more
  • TC-510
  • +2 more
  • Nashville, Tennessee
    Sarah Cannon Research Institute
Jul 14, 2022

Beta-Thalassemia, Thalassemia, Genetic Diseases, Inborn Trial in Nashville (CTX001)

Recruiting
  • Beta-Thalassemia
  • +4 more
  • CTX001
  • Nashville, Tennessee
  • +5 more
Feb 2, 2023

Malignant Epithelial Tumors Trial in Portland (TCR-transduced T cells, CDX-1140, Pembrolizumab)

Not yet recruiting
  • Malignant Epithelial Neoplasms
  • TCR-transduced T cells
  • +2 more
  • Portland, Oregon
    Providence Portland Medical Center
Apr 22, 2022

Sickle Cell Disease, Hydroxyurea Failure, Hydroxyurea Intolerance Trial in Nashville (CTX001)

Recruiting
  • Sickle Cell Disease
  • +4 more
  • CTX001
  • Philadelphia, Pennsylvania
  • +3 more
Jan 24, 2023